A Special Diet for Triple Negative Breast Cancer

A Special Diet for Triple Negative Breast Cancer

There is exciting news in the world of cancer nutrition! For years, the triple negative breast cancer patient has been without a targeted treatment. But, the evidence is beginning to show that some triple-negative specific targeted treatment is on the horizon.

This is great news for you if you want to take back the control cancer has taken from you and reduce your fear around this diagnosis—you are not powerless! This is new information in the triple-negative breast cancer community and it will help you to be an active participant in your cancer treatment and get you on your way to thriving after cancer.

Whether you are a breast cancer patient or survivor or are dealing with another type of cancer, let’s take a look at what these new studies might mean for you…

What is Triple Negative Breast Cancer?

Part of your diagnosis includes a biopsy of your cancer. That biopsy is then sent to the lab where it undergoes laboratory analysis to determine the exact type of cancer and its receptors. In the case of breast cancer, there are three main receptors that have been identified.

What are the 3 main receptors for breast cancer?

  • Estrogen Receptor (ER)—Estrogen drives the growth of this cancer so treatment includes blocking estrogen and/or shutting down production of estrogen.
  • Progesterone Receptor (PR)—Similar treatments are used for PR+ as are used for ER+ including hormone therapy such as Tamoxifen and Aromatase Inhibitors.
  • HER-2/Neu (often just called HER-2) Receptor—Human Epidermal Growth Factor (HER) was discovered in the mid-1980s. This resulted the development of a targeted drug treatment called Herceptin.

A cancer is called Triple Negative—When the pathologist’s tests determine that the cells from the biopsy are negative for estrogen receptors, negative for progesterone receptors, and negative for HER-2/neu receptors aka “triple negative”.

Is Triple Negative Cancer Harder to Treat?

The type of cancer cell found in Triple Negative Breast Cancer is more common in women with BRCA1 gene mutations, younger women, African-Americans and Hispanics. Triple Negative Breast Cancer makes up about 15% of breast cancer cases and is more difficult to treat because it lacks a specific target.

Since it is more difficult to treat, people with this diagnosis can be especially fearful and also feel there isn’t much they can do to help themselves fight against this cancer. I want to share some information about recent studies and scientific evidence to show you that triple negative patients may not be as powerless as they once thought.

Can Diet Help Triple Negative Breast Cancer?

A new diet that uses methionine depletion is being tested as a possible target for triple negative cancers. Methionine is an amino acid that is part of our diet. Researchers at the University of Wisconsin conducted experiments to see how cancer behaves when this amino acid is removed from the diet. Let me say first that this study was conducted in a laboratory with triple negative breast cancer cells in a petri dish (1). The study was not performed on people. But based on the results of the lab study, a clinical trial is underway to do just that.

What Happens When Breast Cancer Cells are Deprived of Methionine? 

Researchers at the University of Wisconsin worked with triple negative breast cancer cells, growing these cells in 1 of 2 different cultures in the lab. One normal culture, called a “control” and one culture that was deficient in the amino acid, methionine. Three different cell types (MDAMB-468, GILM2 and MDA-MB-231) were treated with seven different cancer drugs including lexatumumab.

Results

The cell culture that was deficient in the amino acid, methionine, was found to be moderately toxic to the cancer cells and inhibited their proliferation. The combination of growing cancer cells in the methionine deficient culture plus the drug lexatumumab was the only combination that showed enhanced cancer cell toxicity in all three cancer cell types. A second experiment in which a methionine degrading enzyme (methioninase) showed that this also made lexatumumab more effective.

What Does This Mean for Me?

While the human body is far more complex than cells in a petri dish, this experiment gives us a hypothesis, namely that…

Since restricting methionine for isolated cancer cells is toxic, restricting methionine from the diet of a cancer patient could help to kill cancer cells, reduce their proliferation and make the drug lexatumumab more effective. The next step to testing this hypothesis is an animal model.

Methionine Restricted Diet in Mice with Breast Cancer

Because of the results of the cell studies, the same researchers from the University of Wisconsin tested the methionine restricted diet in mice with breast cancer. The following four treatments were used on the mice:

  1. control group
  2. methionine-free diet alone
  3. lexatumumab alone
  4. methionine-free diet plus lexatumumab.

Results of the Mice Study

All three treatments: methionine-free diet alone, lexatumumab alone and methionine-free diet plus lexatumumab – all inhibited tumour growth compared to the control group. The best result though was in the mice given the combination of the methionine-free diet plus lexatumumab. This group of mice (given methionine-free diet plus lexatumumab) also had less lung metastasis. In fact, the methionine-free diet plus lexatumumab combination was even better at reducing metastases than it was at inhibiting the tumor growth.

What Do These Studies Mean For Me as a Triple Negative Breast Cancer Patient?

The University of Wisconsin researchers state in the publication of the research that “our findings provide proof-of-principle preclinical evidence to support a clinical trial combining dietary methionine restriction and [cancer drugs].” As of the writing of this post 3 trials are currently recruiting subjects.

I will be monitoring for the published version of these studies and will share the information with you. These results are very promising especially for the triple negative breast cancer community that is currently without a targeted therapy. To stay up to date on the latest information and research that will help you to use nutrition to compliment your cancer treatment, sign-up to join my email list. One of many benefits is that you receive in-depth information and updates on new findings in the cancer research world.

Should I Go On A Methionine-Free Diet?

It’s too early in the research process to prescribe a methionine-free diet for triple negative breast cancer patients with confidence. However, a study was performed on eight patients with metastatic cancer done to test whether a methionine-free diet might be safe. The patients were given a very low protein, low methionine diet for an average of 17 weeks and it was found to be safe (2).

What if I Want to Follow a Low Methionine Diet?

I certainly understand if you as a cancer patient or survivor do not want to wait for a clinical trial to finish and the results to be published. I know many of you want to be actively fighting against your cancer and doing everything you can.

So, I want to provide you with some additional information about methionine and a low methionine diet. Since studies have shown a low methionine diet is safe and we know plant-based diets are safe and healthy, following a low methionine diet could be just what you need to help you feel that you are doing more to help reduce your cancer and it’s spread. By actively participating in your care in this way, it can help to give you back some control and reduce some of your fear.

What is Methionine?

Methionine is an essential amino acid. These are the building blocks of protein that we must consume in our diet in our to maintain our health. It is ‘essential’ meaning that we can’t make it in our bodies, but must consume it in our diet.

What Foods Contain Methionine?

The top 100 methionine containing foods are all animal proteins. Turkey has 1.5 g of methionine per 3 oz (90 g) serving followed by (in descending order) whelk, eggs, cottage cheese, beef, chicken, sturgeon, veal, tuna, pork, lamb, quail and pheasant.

Top 500 Methionine-Containing Foods

The top 500 methionine-containing foods include all manner of animal proteins including game meat, goose, ostrich, halibut, trout, snapper, milkfish, duck, mackerel, salmon, swordfish, haddock, parmesan cheese, Pollock, perch, grouper, burbot, mollusks, pike, snapper, herring, tilefish, anchovy, ling, flatfish (flounder, sole or plaice), bluefish, rickfish, tilapia, roe, followed by the final entry out of 500 which is ground chicken with 0.45 g of methionine in a 75 g serving.

What Is A Methionine Restriction?

In one study on the topic (2) of restricting methionine intake, used 2 mg of methionine per kg of body weight.  Let’s calculate this by plugging in our body weight to the calculations below.

Methionine Calculations With Example

Step 1. How much do you weigh? 132 lbs

Step 2. Convert your weight in lbs to kg by dividing your weight in lbs by 2.2 = 60 kg

Step 3. Multiply the methionine level used in the study (2 mg) X your weight in kg (60 kg) = 120 mg

Step 4. Convert mg to g by dividing by 1000 (120/1000) = 0.12 g

As I mentioned above, a 75 g serving (2 ½ oz) of ground chicken had 0.45 g of methionine. So, you can see, that this would already be over the limit of 0.12 g per day.

How Do I Achieve a Low Methionine Diet?

Choosing a diet that is low in animal protein such as a plant-based would lessen your methionine intake. Until more research is known about the actual level of methionine intake necessary and what cancer types and subtypes are more adversely affected by methionine restriction, and what drug regime is made more effective by methionine restriction, it’s hard to get any more detailed at this time. But, in the meantime, I still think this study is relevant for you as a cancer patient, cancer survivor and cancer thriver!

Why Is This Study Relevant for A Cancer Thriver?

This study provides early evidence that nutrition can play a key role both by itself and combined with drug therapy (lexatumumab) to make cancer cells more vulnerable. This is especially relevant for the cells lines that were tested in the study—namely triple negative breast cancer cells. Being able to be part of your care team by following a therapeutic diet will help to keep you in the drivers seat of your own cancer care. Taking back control and maintaining control of aspects of your life, such as your diet, is a big part of being a cancer thriver.

Plant-Based Diets for Cancer Treatment

This study provides more evidence that a plant-based diet is best for cancer patients. It also provides an interesting slant that plant-based diets may not just be useful for cancer prevention but also can be a treatment by itself and to make cancer treatment with lexatumumab more effective. This study has peaked my interest in this topic so I plan to continue to follow it and update you with new teachings. To make sure you don’t miss out, I invite you to join my email list.

Join the Conversation

Do you have triple negative breast cancer? Are you being treated with lexatumumab? Have you been told by your medical professional about a low-methionine diet? I’d love to read your comments below or on Facebook here.

Looking for Additional Reading on this Topic?

Triple Negative Breast Cancer

Receptor Status

ER Negative PR Positive Breast Cancer

Her2- Positive Breast Cancer

Science Daily

References

(1) Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression Clin Cancer Res. 2015 Jun 15;21(12):2780-91. Strekalova E1 et al.

(2) Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction. Nutr Cancer. 2002;42(2):158-66. Epner DE et al.